The main objective of this study is to improve policosanol bioavailability by nanoformulations and encapsulations. Sugarcane wax was extracted from filter muds via supercritical CO<sub>2</sub> technique. Ethyl acetate was used to remove impurities (i.g. phytosterol and chlorophyll ). The ratio of the formulation between modified starch (Hi-Cap 100) and maltodextrin was optimized. The emulsion was dried by spray and freeze dryings. The freeze dried powders which consist of 50:50, 75:25 and 100:0 of Hi-Cap 100 to MD ratios, were 847.80±83.22 nm, 745.07±58.64 nm and 495.43±3.51 nm, respectively. The droplet size of spray dried powder was lower than the freeze dried powder. Moreover, polydispersity index of the droplet size does not exceeded 0.3. X-ray diffraction patterns of pure policosanol, pure starch, purified wax, and dried encapsulated powder suggested that the encapsulated powder was not in the complex form after drying. Freeze dried powder has an irregular shape with small fragments, while the spray dried powder has a spherical shape. The encapsulated powder by spray drying has the higher flow rate then freeze drying.

Encapsulation of policosanol enriched sugarcane wax for food supplement application

253rd National Meeting (2017)

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