Methyl [5-propylthio-1H-benzimidazol-2-yl]carbamate (albendazole) is widely used as anthelmintic for the control of gastrointestinal and lung nematodes. The efficacy of this drug is believed to be partly due to the formation of albendazole sulfoxide (ASOX) and oxfendazole (OFZ) <i>in-vivo</i>. In this work, electrochemical and chromatographic methods were used to determine the electrochemical kinetic parameters for activation of ABZ to ASOX and also to determine the products of the electrochemical oxidation. The electrochemical oxidation at different potentials yielded different products as observed using liquid chromatography coupled to mass spectrometry. The results of electrochemistry of this as well as chromatography are discussed.

Electrochemical oxidation of albendazole on electrode surface: Chromatographic determination of drug metabolites

253rd National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.