Interaction chromatography has found great use for the separation and characterization of complex polymeric systems. To effectively use the interaction chromatography, a good understanding of the theoretical foundation of the interaction chromatography is important. One can gain a good understanding of the separation mechanism through simple Monte Carlo simulations. Simulations allow one to look into how a polymer chain with different chemical composition and/or chain architecture interacts with the column substrates and how that translate into separation seen in experiments. In this talk I will present how we have used Monte Carlo simulations to understand the separation of complex polymers by interaction chromatography. I will focus on the adsorption of polymers in pores studied by Monte Carlo simulations and dicuss the impact of chain architecture on the polymer adsorption.

Theoretical perspective on the separation mechanism of complex polymers by interaction chromatography

253rd National Meeting (2017)

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