This presentation will describe our recent efforts to develop nickel-catalyzed reactions of amides. In particular, the Suzuki–Miyaura coupling, esterification, and transamidation of amide substrates will be described. The reaction conditions employed are relatively mild and are tolerant of a wide range of functional groups. Our studies demonstrate that amides, despite classically being considered inert substrates, can be harnessed as synthons for use in the construction of C–heteroatom and C–C bonds via non-precious metal catalysis.

Recent advances in nickel-catalyzed activation of amides

253rd National Meeting (2017)

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