Incorporating functionalities with biodegradable macromolecular structure, functional polylactides (PLAs) have important applications in polymer-based therapeutics. In particular, the integration of functional PLAs with hydrophilic poly(ethylene glycol) (PEG) chains and other biomedical-relevant functionalities has generated a variety of novel biomaterials with significant application potentials in therapeutic delivery. The development of PLA-based polymer-drug conjugates (PDCs) <i>via</i> multi-functionalization strategy will be presented. Allyl-functionalized PLA is adopted to serve as the precursor of polymer backbones of PDCs. New types of hydrophilic moieties (HM) are studied as alternatives of PEG, leading to a novel class of polymer scaffolds with optimal properties for therapeutic delivery. Meanwhile, various anticancer drugs including gemcitabine (GEM), paclitaxel (PTXL), doxorubicin (DOX) will be functionalized with thiol groups, then grafted onto the functionalized PLAs <i>via</i> thiol-ene reaction. PDCs have been characterized and comprehensively studied. The synergistic effect of combination chemotherapy using integrated nano-systems will also be demonstrated.

Polylactide-based multifunctional biodegradable polymer-drug conjugates

253rd National Meeting (2017)

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