An undergraduate organic chemistry laboratory experiment has been developed that features a discovery-based iodolactonization utilizing a microwave reactor. Microwave-assisted organic synthesis (MAOS) has been widely used in undergraduate laboratory experiments. MAOS offers advantages such as reduced reaction time, increased yields, decreased solvent use, and reduced byproducts, and it allows students to gain a better understanding of how microwave energy heats chemical reactions. Products are analyzed using <sup>1</sup>H-NMR spectroscopy and IR spectroscopy. This modern adaptation of the classic iodolactonization provides the opportunity for discussion of important chemistry concepts, including Markovnikov’s rule and green chemistry.

Microwave-assisted iodolactonization: A discovery-based green chemistry laboratory experiment

253rd National Meeting (2017)

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