In the past two decades, 2D IR spectroscopy has developed into an important tool for probing events on molecular time scales with structural resolution.  For example, hydrogen bond making and breaking events occur on femtosecond time scales and can be linked to strutural fluctuations in complex molecules including proteins, nucleic acids, and polymers.  The use of ultrafast infrared pulses in multidimensional IR spectroscopy techniques, have afforded the timescales of structural fluctuations and solvent fluctuations to be measured and quantified.  However, to fully characterize solvent dynamics, many 2D IR spectra must be collected and analyzed.  For example, for a vibrational probe in a single solvent, typically more than one hundred 2D IR spectra will be collected in order gain quantitative details of the local solvent dynamics surrounding the probe.  Thus, to examine the vibrational probe in solvent mixtures, hundreds of 2D IR spectra are required which correlates to several hours of spectrometer time at a minimum.  In this talk I will discuss our approach to interfacing a 100 kHz repetition rate 2D IR spectrometer with microfluidic technology, thus producing a high-throughput 2D IR spectroscopy platform.  The platform detailed allows roughly 800, fully averaged, 2D IR spectra of five different solvent mixtures to be collected in 30 minutes.<br/>

High-throughput 2D IR spectroscopy platform yields insights into solvent dynamics in solution mixtures

253rd National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.