Plasmonic nanostructures provide an ideal platform for low-volume sample detection and identification using surface-enhanced Raman spectroscopy (SERS).<br/>Yet, overcoming inherent limitations – either from the SERS substrate itself (e.g., distance dependence of the SERS signal) or the lack of affinity for some analytes to adsorb onto bare metal surfaces– requires careful experimental design of the metal-organic interface to enable SERS biosensing.<br/>In this talk I will present recent work on SERS sensors for the qualitative and quantitative detection of glucose. By developing capture layers for the specific capture of glucose, it is possible to directly (i.e. without the need for an external label) this analyte in the physiological range (1-10 mM). I will also describe how such SERS sensors can be used towards the detection of human stress biomarkers.

Towards SERS-enabled diagnostics: Quantitative detection of glucose and other biomarkers

253rd National Meeting (2017)

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