Selective recognition of target pharmaceutical drug molecules from complex biological matrices is a challenging task. There is a wide range of synthetic materials that can be tailored for this purpose however, molecular imprinted polymers (MIPs) offers high sensitivity and unmatched selectivity. Imprinted materials are synthesized in the presence of template analyte molecules where polymeric chains undergoes self-organization phase around template structure following non-covalent interactions for example hydrogen bonding and electrostatic forces. In this study, molecular imprinted polymeric particles are developed for highly sensitive recognition of selected anti-diabetic drugs that usually present in binary dosage formulations. Imprinted polymer particles comprises of poly(methacrylic acid and methyl methacrylate-co-ethyleneglycol dimethylacrylate) using one of the selected template drug. FTIR spectra of imprinted system could be used to study drug-polymer interactions whereas the morphology of the developed product can be viewed by AFM images. The rebinding studies have shown that imprinted polymer possesses high affinity for template drug in comparison to control polymer suggesting the formation of tailored sites in imprinted system. Furthermore, they offer high selectivity and are easy to reuse after regeneration. The results have shown that imprinted materials are potentially favorable for target drug analysis and bioassay studies.

Imprinted polymeric materials for selective recognition of anti-diabetic drugs in complex mixtures

253rd National Meeting (2017)

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