An aminopropyl carbazole (P7C3) was discovered through an in vivo phenotypic screen for compounds that would promote hippocampal neurogenesis. Subsequent chemical optimization provided analogs with improved safety, stability and efficacy. Lead compounds have proven efficacious in multiple models of neuroprotection. For example, they minimize neuron death in the MPTP model of Parkinson's disease, protect motor neurons in the SOD mutant model of ALS, and protect learning and memory in models of traumatic brain injury. Initial studies have indicated that the P7C3 class of compounds maintain NAD levels in neurons, providing a general mechanism for neuroprotection.

Discovery of the P7C3 class of neuroprotective compounds

253rd National Meeting (2017)

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