Kaolin-polyurethane foam composites were developed and characterized for potential application as a durable, long-lasting hemostatic wound dressing material. A series of polyurethane foams with increasing kaolin loading were formulated via a facile, one-pot, and solvent free synthesis. Incorporation of kaolin, up to 25 wt% loading, did not affect the polymerization of the foams. Absence of the isocyanate absorption band in ATR-IR and gel fractions greater than 90% for all foams indicated complete polymerization. DSC and TGA analyses demonstrated that kaolin did not affect T<i><sub>g</sub></i> and degradation onset temperature; additionally, thermal analysis also served to confirm loading concentrations. EDS and XRD provided evidence of thorough dispersion of kaolin at all loading levels. Kaolin significantly reduced polyurethane foam mechanical properties, specifically tensile strength and ultimate elongation. Wound dressing specific analyses comprised ciprofloxacin drug-release and whole blood clotting assay. These materials are able to potentially serve as multi-functional wound dressings.

Kaolin-Polyurethane foam composites for multifunctional wound dressing applications

253rd National Meeting (2017)

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