Six-and seven-membered 1,3-thiaza-4-ones have shown various modes of biological activity. However, the N-aryl compounds have not been widely explored because of the difficulty of coaxing an N-aryl imine into reacting with a thioacid. T3P-promoted condensation of N-aryl-C-aryl imines with thioacids has allowed entry into a wide variety of 2,3-diaryl-1,3-thiaza-4-one heterocycles, and the results to date will be discussed. Synthetic elaboration of these compounds is under investigation and will also be reported on. Testing for anti-microbial activity is also underway and will be disclosed.

More studies on cyclic six- and seven-membered 2,3-diaryl-1,3-thiaza-4-ones

253rd National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.