Cyclic peptide (CP) polymer nanotubes have recently gained much attention for their defined nanoscale diameters and enhanced solubility compared to other nanotubular structures. The solubility of these nanotubes, particularly in water, have enabled them to be developed into potential drug delivery vectors, antimicrobials and biosensors.<br/><br/>Using a ‘bottom up’ approach a new class of model conjugates have been developed to better understand the dynamics of these nanotubes. With known fluorescence studies, such as FRET, we can detect whether the cyclic peptides are kinetically inert or exchanging in solution. Understanding the dynamics and mechanism of these systems will enable us to better tailor the design of future CP polymer nanotubes, to their specific biological application.

Investigating the dynamics of self-assembling cyclic peptide-polymer nanotubes

253rd National Meeting (2017)

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