Although SB-T-1214 has shown high potency and anti-MDR activity towards cancer cells, its systemic toxicity limits the application as an anti-cancer drug. To overcome the drawbacks from lack of specificity and relatively low solubility in water, research on hydrophobic drug delivery system has gained a lot of interests. The gold nanoparticles (GNPs) offer a unique set of chemical and physical properties which make it a potential drug delivery system: 1) The gold core can be easily functionalized with Au-S linkage; 2) Monodisperse gold nanoparticles can be formed with core sizes ranging from 1 nm to 150 nm; 3) The gold core is essentially inert. The nano-sized gold nanoparticles preferentially accumulate within tumors due to enhanced permeability and retention (EPR) effect. By introducing the tumor targeting molecules onto the AuPs, we anticipate to utilize receptor-mediated endocytosis effect (active targeting) together with AuPs’ EPR effect (passive targeting) to increase selectivity toward cancer cells. Biotin (vitamin H) is a water soluble growth promoter of cells. Biotin-specific receptors are often overexpressed on the cancer cell surface. Accordingly, we have designed the biotin-AuPs drug delivery system. The design, synthesis and characterization of this SB-T-1214 and biotin functionalized Gold nanoparticles drug delivery system will be presented.

SB-T-1214 and biotin functionalized gold nanoparticles

253rd National Meeting (2017)

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