Fatty acid esters of 3-monochloropropane 1,2-diol (3-MCPD esters) are a group of potential chemical toxicants. To evaluate the toxic mechanisms of 3-MCPD esters, it is important to clarify their metabolism conditions. In this study, the absorption of 3-MCPD 1-monopalmitate in rat plasma was quantified at different time points after oral administration of 3-MCPD 1-monopalmitate to rats. The greatest concentration (Cmax), time to reach Cmax (Tmax), plasma concentration reduced to half (t1/2), mean resident time (MRT) and the area under curve (AUC) for 3-MCPD 1-monopalmitate in rat plasma was demonstrated. A total of 39 metabolites in rats’ liver, kidney, testis, brain, plasma or urine were identified and relatively quantified after oral administration 3-MCPD 1-monopalmiate. Five possible metabolic pathways were derivate based on the chemical structures of metabolites. These results clarified the major metabolic condition and excreted forms of 3-MCPD 1-monopalmitate in vivo for the first time, and could significantly advance our understanding about the physiological and toxicological properties of 3-MCPD esters.

Absorption and metabolism of 3-MCPD 1-monopalmitate in rats

253rd National Meeting (2017)

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