Palladium-catalyzed ortho-arylation of benzamides was achieved using 2-aminophenyl-1<i>H</i>-pyrazole as a new removable directing group. Employing Pd(OAc)2 as the catalyst and AgO as the promoter, mono- and di-arylation of benzamides may be achieved in good to excellent yields. In the presence of K2CO3, C-C/C-N cyclization products were also obtained.

Palladium-catalyzed ortho-arylation of benzamides using a removable directing group

253rd National Meeting (2017)

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