The study of halogen bonds and their applications in chemistry and biochemistry has become one of the fastest growing research areas in the past decade. Much of this growth is attributed to elegant computational and solid-state studies, whereas the presentation of physical solution data has lagged. This research advances the fundamental understanding of organic halogen bonding by developing simultaneous halogen and hydrogen bonding organocatalysts. Studies investigate preorganization via intramolecular hydrogen bonding in a bidentate bisethynyl pyridinium halogen bonding scaffold. The synthesis, X-ray structures and preliminary binding properties of a new class of charged bidentate halogen bonding catalysts will be presented.

Binding studies and organocatalytic activity of a preorganized bidentate halogen bonding molecule

253rd National Meeting (2017)

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