Kappa- (κ-), iota- (ι-), and lambda- (λ-) carrageenan micro/nanoparticles were synthesized in a single step by using divinyl sulfone (DVS) as crosslinking or by using degradable crosslinkers as trimethylolpropane triglycidyl ether (TMPGDE) via a microemulsion technique. Various cationic groups containing modifying agents such as diethylenetriamine (DETA), triethylenetetramine (TETA), and branched polyethyleneimine (PEI) were used in the preparation modified-carrageenan (m-carrageenan) particles. These m-carrageenan particles were protonated with HCl to increase surface charges of the particles. The antimicrobial susceptibility of the particles were determined by disc diffusion and micro dilution techniques against Escherichia coli ATCC 8739, Staphylococcus aureus ATCC 6538, Bacillus subtilis ATCC 6633, Pseudomonas aeruginosa ATCC 10145, and Candida albicans ATCC 10231. Furthermore, different metal nanoparticles (MNPs) such as Ag, Au, Pt, Cu, Ni, Co, and Fe were prepared within the carrageenan particles in situ and tested for their potential catalytic applications for various dyes and nitro compounds. Moreover, bare and m-, and MNP containing forms of carrageenan particles were tested for sensor application against various analytes. Furthermore, cytotoxicity of carrageenan particles on L929 fibroblast cells, and MDA MB-231 cancerous cells were investigated by WST assay, and their apoptotic/necrotic effects were also determined. Blood compatibility of the carrageenan based particles was determined by protein adsorption, hemolysis and blood clotting tests. Morphological and physicochemical characterization of the particles were determined via optic microscope, SEM, FT-IR, DLS and zeta potential measurements.

Micro/nanoparticles prepared from kappa-, iota-, and lambda-carrageenan for versatile use

253rd National Meeting (2017)

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