We continue to be captivated by biological materials. Although most such systems cannot usually be used, directly, for our needs, we can still benefit greatly by learning from nature. Biomimetic materials often incorporate various design aspects into synthetic systems. A prominent case is that of mussel adhesive proteins. In recent years, there has been a rapid expansion of research effort in which the key adhesive group 3,4-dihydroxyphenylalanine (DOPA) has been placed into several different synthetic polymers. Encouraging results continue to be forthcoming including development of new biomedical hydrogels, sensors, functionalized nanoparticles, and coatings. In terms of adhesion, how close are we to achieving all aspects of the mussel’s bonding function? Some of the aspects unique to this biological adhesive, when contrasted with currently available commercial glues, include an ability to set underwater, creation of strong bonds in such an environment, degradability, modulus tailoring with regard to the substrates, and exhibiting specific protein features including charges. Here we will describe our recent efforts to create more faithful mimics of a fascinating biological underwater adhesive.

Mimicking mussel adhesive proteins: How close can we get to the real thing?

253rd National Meeting (2017)

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