Antibiotic-resistance bacteria (ARB), antibiotic-resistance genes (ARG) and antibiotics, coexisted emerging environmental contaminants, have been identified as a global threat to public health. Photocatalytic (PC), a promising method for water disinfection, was applied to investigate the inactivation mechanisms of ARB and its ARGs as well as the interactions between bacteria and antibiotics.<br/>Results found that ROSs could dramatically damage bacteria, leading to leakage of cytoplasm, proteins and DNA. ARGs were leaked from intracellular into extracellular, then were degraded and even mineralized along with the process of bacteria inactivation. With the coexisted antibiotics during PC treatment, oxidative stress, envelope stress and SOS stress responses were mainly excited, which dramatically upregulated expression of multidrug efflux pumps. This might prevent ROSs from penetrating to intracellular and slow down the inactivation efficiency of photocatalysis. These results can provide the useful information for PC inactivation of ARB, ARGs and more details about interaction of coexisted pollutants.<br/>

Photocatalytic inactivation mechanisms of bacteria as well as the decomposition of Antibiotic-Resistance Genes (ARG)

253rd National Meeting (2017)

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