The goal of our project is to synthesis analogs of Advil, a common over-the-counter nonsteroidal anti-inflammatory drug (NSAID); used for reducing inflammation in pain patients. We have synthesized our compound from salicylaldehydes and ethyl diazoacetate in quantitatively high yields in order to examine the biological effects of our compound. Our lab has already published a faster procedural method for synthesizing different analogs of Advil, in which we are able to produce them in only four steps. Industrially made Advil has a para-isobutyl group on the naphthol structure and is produced using a six-step method, whereas we are synthesizing ours with a para-amino and other related groups on the benzene ring to test its use as an analgesic drug. Due to this change in composition we are unsure if our compound could be used for its original function as a NSAID, therefore we will test the compound’s biological effects. In addition, the synthetic compounds will be tested for anti-cancer agents. This project’s results could potentially have a significant impact on a patient’s health by improving the effectiveness of analgesic drugs with lower toxicity or could also be developed into a new anti-cancer drug. <br/>

Development of new analgesic drugs

253rd National Meeting (2017)

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