Nitrogen heterocycles are critically important structural components of pharmaceuticals. Therefore, general synthetic access to this important functionality is beneficial for medicinal chemistry and drug design.  A new scalable method for synthesis of chiral Aziridines will be presented. This method relies on the use of bifunctional nucleophiles and chiral imines as reaction partners. Optimizations as well as scope and limitations of this new methodology will be discussed.<br/>

Asymmetric vinyolgous aza-Darzens approach towards the synthesis of vinyl aziridines

253rd National Meeting (2017)

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