Polypept(o)ides (polypeptide-block-polypeptoid copolymers) are a remarkable polymeric material because it combines the functionality of polypeptides with the proteinresistance and high water solubility of properties of polysarcosine.(1) The most versatile pathway to both classes of polymers is the polymerization of α-amino acid-N-carboxyanhydrides (NCAs). The ring opening polymerization allows to adjust polymer size, architecture, solubility, functionality and immunogenic properties and enables the incorporation of functionalities beyond nature’s possibilities. Polypept(o)ides can be synthesized by sequential ring opening polymerization using either mono or multivalent initiators, while functional end groups can be easily incorporated by either the initiator or end group modifications after the polymerization. We report on various polypept(o)ide architectures based on different natural and non-natural amino acids having molecular weights from 10 – 50 kDa and a dispersity index below 1.1 and focus on their application as functional surface coatings (macroscopic and nanoscopic surfaces), surfactants or drug delivery systems.

Polypept(o)ides: Combining the functionality of polypeptides with the stealth-like properties of polysarcosine

253rd National Meeting (2017)

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