The increase of bacterial resistance to common antibiotics is recognized as a global health issue. In <i>E. coli</i>, the efflux pump AcrAB-TolC is responsible for multidrug resistance. The synthesis of compounds which bind this system and shut down the efflux of common antibiotics are investigated. Initial screening hits were used as a starting point to establish structure-activity relationships (SAR) and guide synthesis toward more potent analogs.

Synthesis of novel efflux pump inhibitors which target the AcrAB-TolC multidrug efflux system in <i>Escherichia coli</i>

253rd National Meeting (2017)

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Synthesis of novel efflux pump inhibitors which target the AcrAB-TolC multidrug efflux system in Escherichia coli