The synthesis of heavy chalcogen-containing rhodmaine dyes, which have applications as photosensitizers for photodynamic therapy of cancer, extracorporeal photopheresis of malignant T-cells, and graft vs. host disease due to their interactions with P-glycoprotein, mitochondrial localization, and their strong absorption have been described by the Detty group. Additionally, dyes bearing carboxylic, hydroxamic, or phosphonic acid functionalities have been shown to function as metal-free alternative photosensitizers for solar cells. To date, rhodamines bearing thienyl moieties located at the 9-position of the xanthylium core have been examined. However, thieno[3,2-<i>b</i>]thiophene, 2,2’-bithiophene, and 2,2’:5’,2”-terthiophene derivatives have yet to be investigated. The synthesis of these new polythiophene derivatives and preliminary biological and photochemical data obtained from collaborators will be described.

Synthesis and evaluation polythiophene containing rhodamine dyes for biological and photochemical applications

253rd National Meeting (2017)

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