Block copolymers hold crucial importance in bio-technological fields for drug delivery and tissue engineering due to their self-assembling properties in both aqueous and non-aqueous emulsion (NAE). Frequently, Poly(L-lactide) (PLLA) is used owing to its good mechanical properties, biodegradability and biocompatibility. PLLA based nanocarriers can be generated through several techniques, such as self-assembly of polypeptide-based block copolymers in NAE or by designing PLLA-based amphiphilic block in aqueous media. For these reasons, we have developed a polylactide-based functional block copolymers, poly(L-lactide)-<i>block</i>-poly(serine ester), with different block ratios via ring opening polymerization (Fig1.).<br/>Using these pseudo-poly(amino acid)s, which are structural analogues of conventional poly(α-amino acid)s, functionality is added to the copolymer shell, which makes them effective for targeted cancer treatment or interaction with the cell-medium. Furthermore, such functional carriers are exclusively made of non-toxic and biodegradable polymers, making them suitable candidates for medical applications.

Synthesis and self-assembly of amino functional AB-type biodegradable block copolymers

253rd National Meeting (2017)

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