Gut microbiome have recently provided evidence that gut microbiota are capable of greatly influencing all aspects of physiology, including obesity. Accumulating results have shown that the mechanisms by which lactic acid bacteria reduce obesity are associated by alteration of microbial composition. Two probiotics candidates, Pediococcus inopinatus WIKIM27 (PI) and Lactobacillus sakei WIKIM31 (LS) isolated from kimchi were individually administrated to high fat diet (HFD)-fed mice for 10 weeks. Supplementation of PI and LS reduced body weight gain and body fat mass accumulation and improved liver function. Weighted UniFrac analysis based on next-generation sequencing of cecal bacterial 16S rRNA genes using an Illumina MiSeq instrument showed that both PI and LS improved the overall structure of the HFD-disrupted gut microbiota. Redundancy analysis exhibited that abundances operational taxonomic units (OTUs) of commensal probiotics such as Bacteroides and Akkermansia were increased by PI and LS administration, respectively. In addition, increases of Bacteroides and Akkermansia OUT significantly correlated with several host obesity-related parameters such as body weight gain and adipokines. In this presentation, we will discuss the current knowledge how the probiotics can influence the gut microbiota and the potential use of probiotics isolated from fermented foods in obesity for therapeutic purposes.

Lactic acid bacteria isolated from kimchi as a modulator of gut microbiota in diet-induced obese mice

253rd National Meeting (2017)

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