Sodium-dependent glucose cotransporter1 (SGLT1) and glucose transporter (GLUT) are abnormally expressed in cancer cells. Increase of glucose uptake in cancer cells causes the resistance of genotoxic agents. It suggests that blocking glucose uptake have the potential to increase the efficacy of anti-cancer agents.<br/> In this study, we focused on the small molecules drug conjugation for colorectal cancer. 5-FU and irinotecan, are common requirement for colorectal cancer, were conjugated with SGLT1 & GLUT inhibitors, through acid-labile linker and bio-reductive linker. New conjugations were evaluated for found their anti-cancer effect.

Genotoxic agents conjugated inhibitors of glucose transporter for anti-colorectal cancer

253rd National Meeting (2017)

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