Many materials and approaches have been applied to achieve the drug delivery to cell. Metal Organic Cages have large hollow cavity, solubility, high mono-dispersity, tunable functionality, and are very suitable molecular vehicle for drug delivery or similar purpose. Here we synthesized the largest octahedral Metal Organic Molecular Cage-1 (MOMC-1) with large hydrophobic cavity and intrinsic fluorescence. The large hollow cavity (3.1 nm) can bind anti-caner drugs camptothecin (CPT) and can only release the drug in low PH environment like cancer cell. The fluorescent property of the drug carrier can determine the drug distribution inside the cell. More importantly, this drug vehicle with a diameter of 5.0 nm can efficiently penetrate the nuclear membrane, followed by concentrating inside nucleus and delivering the anticancer drug into the targeted nucleus, obtaining much better cryotoxity. Overall this novel mono-dispersed drug delivery vehicle with large cavity exhibits facile preparation, efficient drug loading, excellent nuclear penetrating and cell imaging, and significant anti-tumor cell effects.

Build-In fluorescent M24L8 octahedral metal organic molecular cages for nuclear-penetrating PH-responsive drug delivery

253rd National Meeting (2017)

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