This lecture will focus on the catalytic enantioselective construction of carbon-fluorine bonds with electrophilic fluorinating reagents. The development of a strategy based on the delivery of cationic fluorinating reagents by means of chiral anion phase transfer catalysis (CAPT) will be discussed. The CAPT methods allow for the generation of C-F bonds through direct fluorination of nucleophiles or by fluorocyclization reactions of alkenes. A complimentary approach involving transition-metal catalyzed enantioselective C-F bond constructions will also be introduced. The transition metal-based appraoch allows for the generation of complexity through the simultaneous formation of C-F and C-C bonds.

Enantioselective methods for carbon-fluorine bond construction

253rd National Meeting (2017)

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