Cyclodextrin polymers (CD-polymers) offer several advantages compared to native CDs with respect to the development of complex therapeutic drug delivery vehicles. Since CD-polymers contain several functional CDs units they can be used for macromolecular assemblies such as nanoparticles and hydrogels, enabling controlled release of drug compounds. In recent years CD-polymer based nanoparticles have found use as therapeutic vehicles in delivery of e.g. anticancer agents and siRNA. Here we present versatile and reliable synthetic approaches towards well-defined CD-polymers. The polymers have been prepared by means of RAFT-polymerization and Copper(I) catalyzed Azide-Alkyne Cycloaddition. Furthermore their formation of various stimuli-responsive nanoparticles will be presented.

Stimuli responsive nanoparticles from cyclodextrin polymers

253rd National Meeting (2017)

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