The new functional materials and efficient approaches for protein sensing is promising for understanding the molecular mechanism of signal transduction pathways and developing antagonists for therapy. In our recent study, we have designed and developed a novel and unconventional hybrid material consisting of graphene oxide (GO) and cationic conjugated polymer for detection of the conformation transition of a cellular Ca2+-binding protein of 148 calmodulin (CaM) by using fluorescence resonance energy transfer (FRET) technique. This effort provides first example of how FRET technique can be used with emerging types of graphene oxide and optical functional materials in order to detect CaM and its conformation change not readily obtained otherwise. We also have developed a water-soluble poly(phenylene vinylene) derivative (PPV-NMe3+)-based system to detect and inhibit the HEWL aggregation triggered by UV illumination. PPV-NMe3+ will be of theoretical and practical significance for the better understanding of protein aggregation and provides an efficient strategy to prevent and treat diseases caused by proteins aggregation. This system will produce a profound influence on the future protein drug development, meaningful for the realization of the rapid commercialization of protein drug.

Graphene oxide-conjugated polymer hybrid materials for protein sensing

253rd National Meeting (2017)

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