The layer-by-layer approach can be used to generate finely tuned release surfaces that can release small molecule, proteins, nucleic acids and other biologic drugs over sustained time periods, and with significant control of release characteristics.  Using as few as 3 or 4 bilayers to tens of layers, we can generate thin films with demonstrated therapeutic efficacy over a broad range of efficacy.  Furthermore, the use of ultrathin barrier layers in between sets of multilayers can yield staged release of therapeutics from large, macroscopic surfaces such as biomedical devices and implants to microstructured arrays and nanoparticle surfaces.    This approach is particularly attractive for the delivery of proteins and nucleic acids such as siRNA and DNA that can be used for immunomodulatory applications, including the release of antigens and adjuvants that may be designed to address cancer, infectious disease, or immunological disorders.  Proteins, adjuvant, siRNA and DNA can also be released from microscopic and millimeter scale structured surfaces for localized delivery directly to the skin’s dermis layer, which is a site highly populated by dendritic cells as well as T and B cells. Multilayer “tattoos” derived from the transfer of LbL films with microneedles for transdermal delivery of DNA vaccines provides a promising route to address vaccination of difficult to target diseases.    Approaches in our lab focused on nanoparticle and microneedle delivery approaches in collaboration with the Irvine lab at MIT to modulate the immune system will be addressed.<br/>

Nanolayer assembly as a platform for immunomodulatory release systems

253rd National Meeting (2017)

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