Skin burn wound injury is one of the most common household injuries, ranked fourth in all injuries. It can severely affect not only the skin but the whole body depending on their depth and extension, first-, second- or third-degree burn. For a burn treatment, a bacterial cellulose (BC) has been a new proposition, which has been constantly developed. Interestingly, BC was found to be a promising material for wound dressing due to its fibril network structure, which is very similar to the extracellular matrix of human skin, and its outstanding holding water capacity, high tensile strength, high purity and biocompatibility. In this study, BC incorporating with violet silver nanoprisms (AgNPrs) will be developed. Synthesis of violet AgNPrs was carried out through a shape transformation reaction which accomplished by reduction of silver ions with NaBH4 in the presence of H2O2 and using SDS as the polymeric stabilizer. Moreover, an aloe vera extract (ALO), a anti-inflammatory agent was used to promote healing properties. Therefore, a combination of AgNPrs contents and various concentrations of ALO loaded to BC matrix were studied. Physical and chemical properties of dressing were optimized. In addition, cytotoxicity test with mouse fibroblast cells (L929) and antibacterial activity against E.coil and S.aureus of BC-V-A film were determined to confirm that the developed dressing can be used in human skin safely.

Development of Aloe vera/ violet silver nanoparticles/bacterial cellulose film for using as burn wound dressings

253rd National Meeting (2017)

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