Abstract Adventitious agent contamination of bioreactors and upstream environments are rare events; however, consequences are catastrophic when they occur. Since some raw materials (eg, amino acids, growth factors) used in biologics manufacture are relatively labile, invasive physical methods such as heat or irradiation may not always be applicable as these methods have the potential to influence growth media quality and thereby impact cell metabolism and therapeutic protein production. The recently introduced Virosart® Media Filter is a risk mitigation filter that provides contamination control for bacteria, mycoplasma and viruses. The Virosart® Media Filter is a high flux, virus retentive filter, specifically designed for upstream risk mitigation to minimize contamination from viruses, bacteria, and mycoplasma.

Evaluation of the Virosart® media filter for application in upstream risk mitigation for adventitious agent contamination

253rd National Meeting (2017)

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