Carbohydrates are the most abundant organic species in the world and also one of most important biological macromolecules with nucleic acids and proteins. The self-assembly of DNA and proteins make a significant contribution to our lives and they have been employed to make functional self-assembled materials. Compared to the development of DNA and proteins, our knowledge and manipulation to the self-assembly of carbohydrates as well as their functionality are quite limited. The major obstacle is the complicated chemical structure of oligosaccharides, i.e. perplexing glycoforms and microhetrogeneity on proteins, which make the research a problematic and long-term task. Under this circumstance, macromolecular self-assembly might provide an alternate insight to this problem. In this talk, I will present: 1) developement of precise protein array with regular shape at mm scale controlled by protein-carbohydrate interaction; 2) construction of polymeric vesicles mimicking <i>glycocalyx, </i>structure, self-assembly and immunological functions; 3) control of macromolecular self-assembly by chemical reactions related to sugars.

Carbohydrate-based macromolecular self-assemblies and their biological functions

253rd National Meeting (2017)

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