Polymer particles can be used for many purposes, including bio- separation, sensing, coating, and so on. For these applications, it is necessary for the particles to have properties, such as bioinert interface and selective adsorption capacity for target molecules, such as drugs and pollutant. In this study, blood compatibility poly(2-methoxyethyl acrylate), pMEA, was selected for the framework of particles, and they showed the selective adsorption behavior of halide compounds, which were necessary to be delivered as a drug and separated from wastewater. In particular, the oxygen atom of methoxy group in pMEA side chain terminal, which usually bonded the freezing bound water (intermediate water), played an important role for the halogen bonding, resulting in the strongly maintenance and the difficult desorption of halide dyes from the surface of pMEA. Indeed, the pellet of pMEA was stained easily with red color of erythrosine after centrifugation (<b>Figure</b>). Moreover, to increase the dispersion stability and release efficiency of target halide molecular for pMEA microspheres, the stimuli-responsive pMEA nanocomposite hydrogel particles were synthesized by precipitation copolymerization of pMEA and the poly(oligoethylene glycol methacrylate) as the microgel backbone, which display a lower critical solution temperature in water. The pMEA composite hydrogel particles also showed the specific adsorption behavior of halide compounds, and the release efficiency of the halide compounds was able to be controlled by changing temperature. These detailed results will be discussed at the session.

Synthesis of poly (2-methoxyethyl acrylate)-based hydrogel particles for bio-coatings and carriers

253rd National Meeting (2017)

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