A simple and fast protocol to determine the absolute stereochemistry of a variety of chiral molecules is introduced here. A simple one step coupling of chiral molecules (amines, alcohol or carboxylic acid) with 1,1'-(bromomethylene)dinaphthalene (BDN) or di(naphthalen-1-yl)methanol (DNM) leads to the active CD signal. Computational analysis helps to determine the absolute stereochemistry of the parent molecules. The utility of this methodology will be put to test in a High Throughput Screening Process for chiral amines, in order to evaluate it potential application as a tool that complement reaction discovery.

Sensor of chirality and enantioselectivity for enantio-enriched molecules containing amines, alcohols, and carboxylic acids

253rd National Meeting (2017)

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