Dendronized polymers are formed through densely attaching dendrons along a linear polymer main chain, which adopt cylindrical wormlike morphology with tunable thickness. Inspired from the smart properties of biomacromolecules in nature, an intriguing class of stimuli-responsive dendronized polymers were constructed through combination of dendritic oligoethylene glycols (OEG) with various kinds of polymer backbones. Due to the densely covered OEG pendants, these macromolecules show unprecedented thermoresponsiveness and excellent biocompatibility. This presentation will discuss our findings in developing versatile thermoresponsive warm-like dendronized polymethacrylates and polypeptides by decorating with dendritic OEG pendants through covalent linkages, dynamic covalent linkages or supramolecular interactions (Figure 1). Depending mainly on the molecular topology, amphiphilic structure in these dendronized polymers plays different roles on mediating their stimuli-responsive properties. Based on the thickness effects, dendronized polymers undergo heterogeneous dehydration and collapse on individual molecular level. Therefore, guest molecules can be encapsulated and released based on the phase transition temperature, heating rate and thickness of the polymers, resulting in interestingly the formation of molecular containers. This encapsulation property afford these thick polymers tunable shielding ability to protonation and metal coordination in aqueous solutions. In a word, combination of unique thermoresponsive behavior, reversible encapsulation and switchable shielding to guests, protonation as well as metal coordination from these OEGylated dendronized polymers may lead to their promising applications in biomaterials, including drug delivery and targeting, enzyme activity control and transportation.

Stimuli-Responsive dendronized polymers for next generation biomaterials

253rd National Meeting (2017)

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