Mobile zinc signatures can be used as a biomarker for prostate cancer prediction, opening the route for the early diagnosis of cancer. Clinicians need a reliable tools which can offer fast, highly sensitive and selective mobile Zn(II) concentration in live cells. Here we will discuss our recent reports on the design of novel and highly efficient surface enhanced Raman spectroscopy (SERS) probe using <b>p-(imidazole)azo) benzenethiol attached gold nanoparticle</b> as a Raman reporter, which has the capability to identify prostate cancer cells based on Zn(II) sensing. Reported data show that SERS probe can distinguish metastatic cancer cells from normal prostate cells very easily. Designed Raman  probe has the capability to be used as chemical toolkit for determining mobile Zn(II) concentrations in the biological sample.

Screening of prostate cancer cells using Zn(II) sensing SERS nanoprobe

253rd National Meeting (2017)

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