Biologically inspired catalysts are currently explored in the quest for novel reactivities and selectivities that could complement those attained with traditional reagents in selective C-H and C=C oxidation reactions.1 Towards this end, iron coordination complexes ligated to amine and oxygen containing functionalities, and that could be viewed as a minimalistic model of iron coordination sites in non heme iron dependent oxygenases, are employed as catalysts for the oxidation of organic substrates. By control of their structure and electronic properties, catalysts have been designed by our research team that engage in controlled O-O lysis of H2O2 to form highly electrophilic high valent metal-oxo species that are finally responsible for enzyme-like selective oxidation chemistry.2 Incorporation of these simple coordination compounds into elaborated ligand scaffolds, that provide a second coordination sphere, introduce novel selectivity properties. Principles of catalyst design and use of these catalysts in selective C-H and C=C oxidation reactions, and reaction intermediates involved in these reactions3 will be presented.

Rational design of biologically inspired catalysts for selective oxidation reactions

253rd National Meeting (2017)

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