Chromone is a privileged structure, and its derivatives have potential for use in medicinal products. In this study, 2-aminopyrimidine and 4-aminoantipyrine analogues of chromone were synthesized using a one pot microwave-assisted reaction. Green chemistry techniques were utilized though the use of the microwave reaction condition and green solvents such as ethanol. The vinylogous 4-aminoantipyrine imine derivative was then reacted using a triethylborane mediated radical addition with a variety of different radical precursors, both nucleophilic and electrophilic, in order to create a wider variety of analogues. We will also present the results of organocuprate additions to the imine.

Microwave synthesis and functionalization of vinylogous imines

253rd National Meeting (2017)

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