Epidemiological data supports an association between high levels of high density lipoprotein (HDL) cholesterol and lower cardiovascular risk. Results from clinical trials over the past decade have shown a link between moderate coffee consumption and higher levels of HDL cholesterol, although the molecular mechanisms for how coffee or its constituents regulate HDL metabolism are yet largely unknown. HDL plays an essential role in plasma lipid transport. It provides a reservoir of C apolipoproteins, which are required for the metabolism of chylomicrons and very low density lipoproteins (VLDL), and acts as a scavenger of surplus unesterified cholesterol from these lipoproteins. HDL is also the major vehicle for the transport of cholesterol from peripheral cells to the liver for cholesterol catabolism and excretion. This mechanism explains the protective role of high HDL in cardiovascular events. The here presented paper will review clinical data on the efficacy of coffee consumption in reducing plasma HDL. Moreover, mechanistic in vitro data on individual coffee constituents regulating cellular targets of HDL metabolism, transport and excretion will be presented. This data provide novel insights into how coffee constituents may help to raise and/or maintain beneficially high plasma HDL levels. <br/>

Identification of coffee constituents with beneficial effects on cholesterol metabolism

253rd National Meeting (2017)

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