Plants produce a variety of rare natural products which are used in our daily lives as flavors, fragrances, food ingredients, cosmetics, vitamins, pharmaceuticals and agricultural chemicals. Despite their intrinsic value, however, sourcing remains a bottleneck to more widespread use due to their low abundance in nature. Manus Bio has developed the world's best platform technology for engineering cell factories grounded in modular and data-driven design and patented a commercial organism which can produce a myriad of typically ultra-rare and costly ingredients used in our daily lives. These cellular factories are capable of converting carbon feedstock to product at high yields and have been adapted to produce a mature pipeline of products, or "BioAssemblyLine." In order to engineering our “BioAssemblyLine”, we integrate three core technologies - our proprietary Multivariate Modular Metabolic Engineering (MMME), Pathway Integrated Protein Engineering (PIPE) and Integrated Multivariate Omics Analysis (IMOA) platforms. With this approach, we have successfully developed cell factories with a total addressable market of $7B and with the potential to expand to other products with more than $100B+ market value. In this presentation, we will highlight some of the important insights and guiding principles used to engineer our “BioAssemblyLine” cell factories. Ultimately, we strive to reduce our dependence on land- and resource-intensive practices by recreating natural processes through biotechnology to meet the consumer needs of a developing world.

Industrialization of biology: Making nature accessible and affordable

253rd National Meeting (2017)

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