Amides were synthesized from anilline derivatives through a TiO2 catalyzed continuous flow reactor with a controllable pressure system. Prior to this contribution on this project, temperature, flow rate and stoichiometry were varied to produce optimal reaction conditions. Those conditions being 200 oC, a 0.50 ml/min flow rate, and a 1:8:1:4 (aniline:nitrile:H2O:THF) molar ratio. In efforts to obtain higher yields collection time and column inner-diameter were varied. By varying these conditions, collection time was optimized at ~2 h. A 5 micron fritted column consistently gave higher yields, where as the 2 micron fritted column was less consistent in obtaining high yields and more prone to clogging.

Pressure controlled continuous flow reactor synthesis of amides from aniline derivatives

253rd National Meeting (2017)

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