253rd National Meeting (2017)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

American Chemical Society

Current Topics in Biochemistry

Developing a pipeline for generating TNA-phosphoramidite and TNA-triphosphate monomers for the in vitro evaluation of the properties of the polymers

Characterizing the genetic fitness landscape of virus-like particles

Development of a cannabinoid-based Cell-in-a Box® therapeutic system targeted toward malignant tumors

Synthesis of 2-Arachidonoylglycerol: An endocannabinoid with potential as an anti-cancer drug

In vitro anti-neoplastic activity of specific phytocannabinoids of Cannabis sativa

Design, synthesis, and conformational analysis of proposed β-turn mimics from isoxazoline-cyclopentane aminols

Bioorthogonal near-infrared fluorogenic probe for mRNA detection

Binding mechanism study of coomassie brilliant blue species and bovine serum albumin

Parallel stranded G-quadruplex composed of Threose Nucleic Acid (TNA)

Analysis of chemotypes in retail Cannabis strains

Construction of hydrophobic nanoparticles based surface plasmon resonance biosensor for lysozyme detection

Glycoconjugated site-selective DNA-methylating agent targeting glucose transporters on glioma cells

Is it a biological response or chemical process? Chemical and transcriptional regulation experiments probe the cause for the increased accumulation of Chlorogenic Acid (CGA) in carrot root slices exposed to UV-B light

HPLC analysis of sulfation of dopamine derivatives by SULT1A3

Effects of heterocyclic diamidine antiparastitic agent binding to DNA on restriction enzyme kinetics

Proline-rich peptides inhibit polymerization of sickle cell hemoglobin

Influence of loop mutations on G-quadruplex unfolding

Conformational sampling and non-dimer aggregates of HIV-1 protease containing darunavir promoted mutations

Successful screening of aptamers for an early diagnosis of a periodontitis

Insight into the mechanism of a bifunctional diguanylate cyclase enzyme in Agrobacterium vitis: A catalytic loop 6, nitric oxide signaling and bacterial biofilm formation

Isolation, structural elucidation and biosynthetic characterization of HIV-1 Nef accessory protein inhibitors

Evaluating the effect of lipophilicity on antimicrobial potency, cytotoxicity, and combinatorial library design

Reactivity of bovin serum albumin with ligands of cisplatin analogs

Investigation of the effect of gold nanoparticles on the structure and catalytic function of Escherichia coli prolyl-tRNA synthetases

Investigation of Cu(II) complexation with fourth microtubule-binding repeat of tau protein by ESI-MS, IMS-MS and NMR

Purification and kinetic assays of recombinant AaCHYMO from the Aedes aegypti female mosquito

Comparison of synthetases in the incorporation of the non-natural amino acid p-azidophenylalanine in the oncogenic protein kRas

5-azidomethyl-2’-deoxyuridine triphosphate can be efficiently incorporated by a repair DNA polymerase

Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors

Development of highly specific carbohydrate-nucleic acid reagents for lectin recognition

Discovery of endogenous and synthetic ligands for orphan nuclear receptor TLX

Enzyme-enzyme proximity stimulates iNOS activity

Synthesis of solvatochromic probes to study the effect of host microenvironment on mycobacterial cell wall dynamics during infection

Toward Raman-based diagnostics for amatoxins: Synthetic, computational, and spectroscopic studies on analogs for the substituted tryptathionine sulfoxide core of amanitins, the peptide toxins of Amanita phalloides

Supramolecular assembly of artificial metalloenzymes: Influence of the second coordination sphere of the LmrR in catalysis

Hyper obesity suppression by the products of Rhinacanthus nasutus: A study in rats

Enzymatic site-specific labeling with RNA-TAG for affinity purification of RNA-protein complexes

Development of a fluorescence polarization assay for RhlI

Plausible reaction mechanism of the deamination of histidine catalyzed by histidine-ammonia lyase

Synthesis and evaluation of a norbornene containing substrate for protein farnesyltransferase

Cloning of IME4 to establish a new model system to probe N6-methyladenosine modification of mRNA

Allosteric inhibition via two-step enzyme isomerization of human herpesvirus protease protein-protein interaction decreases viral infectivity of Kaposi’s sarcoma-associated herpesvirus in mammalian cells

Developing FRET assays to study the binding and regulation of fibroblast growth factor to its receptor

Fourier transform infra red spectroscopy based spectral biomarker identification: Applications in classifying lung cancer subtypes

Fibrinogen αC (233-425): A model protein for characterizing cross-linking by the transglutaminase factor XIII

Fine-tuning triazabutadiene stability for controlled aryl diazonium release

Tat-specific factor 1’s role in HIV RNA stability

Ca2+ induced conformational changes of calmodulin and troponin C chimera

Chemo-enzymatic synthesis of an effective bifunctional NAADP analog for isolation and purification of the NAADP receptor

N acetyl cysteine as an inducer of retina regeneration

Quantification of the minimum numbers of TLR2 agonists necessary to elicit a detectable immune response

Quantifying the relative amounts of PrP polymorphisms present in prions isolated from heterozygous prion-infected animals

Allosteric control of histone demethylase KDM5A

Synthesis of fluorogenic phosphatidylcholine derivatives for kinetic studies of phospholipase A2 enzymes

Understanding the structures and dynamics of type II carrier proteins using molecular dynamics simulations

Possible prebiotic fabrication of ribonucleotides using microdroplets

DNA Editing in DNA/RNA hybrids by adenosine deaminases that act on RNA

Affinity ligand purification for pyridine dinucleotide binding proteins

Investigating a new paradigm in melanocortin signaling and energy balance

Pathological mutations in the prion protein modulate the metal driven cis interaction

Engineering a polymerase for accurate bypass of damaged DNA samples

Elucidating Met18 functionality in iron-sulfur cluster biogenesis pathway

Development of novel substrate inhibitors of bacterial phospholipid biosynthesis as new antibacterial agents

ROS responsive self-cyclization for hydroxyl radical detoxification

New design for twin reactive oxygen species activated anti-tumor agents

Cryptic antibiotic discovery in the filamentous cyanobacterium Scytonema sp. UTEX LB 1163

Structural analysis of tau peptide interactions with lipid membranes using Fourier transform infrared spectroscopy

Photo-uncaging of reactive species and fluorescence with visible light and NIR

Mutational studies of a deoxyribozyme by high-throughput sequencing

Inhibition of fibrillar assemblies of l-phenylalanine by crown ethers: A potential approach toward phenylketonuria

Examination of essential genes involved in the biosynthesis of key metabolite by Chlamydia trachomatis

Copper containing sulphonamide analogs for biological targets

Exploiting the peptide-binding site to design inhibitors of the KDM4 subfamily

Investigating the conformational landscape in a signaling protein complex with optical tweezers

5-Hydroxymethylcytosine impacts Holliday junction structure to promote recombination via recognition by Endonuclease G

Investigation of oligomeric assemblies within the claudin tight junction protein family: A combined computational and experimental approach

Clarification by floculation: A promissing solution for high cell density

Development of targeted stigmasterol-solid lipid nanoparticles by hyaluronic acid and transferrin for lung cancer therapy

Investigating the specificity of methylated DNA binding by MBD1 and mutant peptides for transcriptional regulation

Computational study of relative thermodynamic stability of mutant base pairs between keto, enol and deprotonated forms of guanine and thymine at DNA polymerase λ active site

Effects of DNA bending on T=C CPD deamination

Nucleobase analogs as probes for substrate recognition and repair by DNA glycosylase MutY

Efficient method to study engineering temperature shift strategies for Chinese hamster ovary cell culture via mechanistic macroscopic kinetic modeling

Heteromultivalency in melanoma with GPCR ligands: Target validation and use of orthogonal chemistries towards a heterobivalent scaffold

Optimizing the production of FOXA2 to unravel the interaction between homeodomain and Forkhead transcription factors

Utilization of extracts of garlic, oregano, neem and a commercial insecticide on endophyte bacteria on orange leaves infected by citrus greening

Cartilage: Function and supramolecular structure

Exploration of the N-terminal extension’s role in human gamma-S crystallin function

Chemical biology approach for dimethyllysine incorporation into proteins

New tools for controlling the supramolecular assembly of proteins in living cells

Structural analysis of heme c motifs for the template-based design of heme c proteins

Novel application of TEC-disulfide replacement showcased in the synthesis of SFTI-1

Unnatural lysine analogues to mimic the catalytic pocket of human DNA polymerase β

Self-assembled synthetic ion channels

Synthesis & spectroscopic characterization of xenometabolite, biomarkers for the diagnosis of fatty acid β-oxidation disorder

Study of aminoglycosides binding to mitochondrial rRNA

Allostery and catalysis of UDP-sugar pyrophosphorylases suggest a new approach to anti-parasitic treatments

Role of miRNAs in chick retina regeneration

5′ Start site heterogeneity of the HIV-1 RNA and its effect on structure and function

Measuring metabolite consumption by Sinorhizobium meliloti using 1H NMR spectroscopy and time domain Complete Reduction to Amplitude Frequency Table (CRAFT)

Current Topics in Biochemistry

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Developing a pipeline for generating TNA-phosphoramidite and TNA-triphosphate monomers for the <i>in vitro</i> evaluation of the properties of the polymers