In biological fluids, drug delivery systems can reduce side effects of toxins and create an appropriate concentration of drug at the treatment site. Chitosan hydrogel have become a potential drug delivery systems for carriers of bioactive compounds. Biodegradable and biocompatibility of chitosan have been interested in preparation of carrier systems. Chitosan film was prepared by solvent casting method and evaluated them in terms of uniformity, swelling rate and disintegration time, it was used as a drug delivery system of podophyllotoxin. The drug release rate follows the first order model. Converting chitosan to co-polymer chitosan-acrylamide improves drug delivery rate and provides the opportunity to use it. We prepared chitosan, montmorillonite (MMT) nanocomposite as a natural- based nanocomposite film .It was made by mixing of two different concentration of clay particles suspension in a chitosan solution. The preparation of organo-montmorillonite removed trapped water molecules from the montmorillonite, and formed composite film without bubble, as shown by the DSC analysis.<br/>

Preparation of cross-linked chitosan hydrogel as a drug delivery carrier of podophyllotoxin

254th National Meeting (2017)

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