Polymer drug carriers based on N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymers bearing cholesterol moieties have been studied extensively over the past few years, to understand the aggregation behavior and shape of the copolymers in dilute aqueous solutions. Above certain concentration, micelle-like nanoparticles (NPs) having ellipsoidal shape are observed. However, there is a lack of knowledge on the behavior of these drug carriers in human blood environment. Human serum albumin (HSA) was chosen for this study as a basic protein, which is the main component of human blood plasma. We use fluorescence life-time correlation spectroscopy (FLCS), isothermal titration calorimetry (ITC), nuclear magnetic resonance (NMR), and small angle X-ray scattering (SAXS) to investigate HPMA copolymers that are dissolved in an aqueous solution of HSA to reveal the interaction between the NPs and HSA.<br/>This research was funded by a grant No. 15-10527J the Grant Agency of the Academy of Sciences of the Czech Republic.

HPMA-based drug delivery system and its interactions of human serum albumin: SAXS, ITC, and NMR study

254th National Meeting (2017)

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