The formation of branched polymers using multi-vinyl-monomer strategies has led to new opportunities to control the architecture, chemistry and function of a range of macromolecules towards specific applications. In particular, the control of polymer chain chemistry and the ability to tailor chain-end functionality through mixed initiation routes has allowed the iterative optimization of polymer design for processes such as nanoprecipitation. Herein, we present the design and synthesis of one-pot amphiphilic emulsion stabilizers. The careful control of mixed internal phases with varying volatility has allowed the generation of stable macroemulsions and nanoemulsions with controlled diameters that are able to solubilize drug compounds within the dispersed phase. Drug-loaded nanoemulsions, containing relevant concentrations of antiretrovirals for HIV therapy, have been studied on storage, for inherent toxicity and utilized in <i>in vitro</i> gut permeation models to simulate oral dose and passage of drug through gut epithelium into the blood stream. Also, thiol-functional emulsions have shown clear interactions with mucus allowing targeting and triggered release. It is clear that drug absorption may be aided by the nanoemulsions and also that the potential to overcome efflux pumps and encourage poorly-absorbed drugs to enter the systemic circulation may also be achieved.

New branched polymer architectures for nano and macro emulsion stabilisation and targeting/delivery of therapeutic molecules

254th National Meeting (2017)

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