Direct visualization of life processes at the individual protein level would provide unique insights into how biology functions and organizes, but has been technically challenging, even for in vitro settings. I describe our recently developed experimental platform that zooms into individual biomolecules in solution, traps them one at a time and simultaneously measures multiple physical parameters of single molecules. I will describe on-going projects that leverage these new technologies to dissect protein assembly pathways and DNA-protein interactions.

New variables to dissect in vitro biochemistry with single-molecule resolution

254th National Meeting (2017)

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